Cardiothoracic surgeons are studying the use of artificial intelligence (AI) and machine learning (ML) to improve risk prediction in the hopes that patient outcomes also will improve. Arman Kilic, MD, and Ara A. Vaporciyan, MD, along with medical student Brian Ayers, discuss what AI and ML mean, how it can uncover previously unknown relationships in medical data, and how it can be used to assist the surgeon in the operating room.